Mode of Action

Technological Advantage

The biopesticide formulation is conventionally applied to the crop, while the encapsulating agent prevents the RNA molecules from environmental degradation, ensuring it remains available on the plant surface for uptake by feeding insects.

As the CSFB emerges and feeds on the treated crop, they simultaneously ingest lethal doses of our RNA-based biopesticide, capable of withstanding the harsh gut environment within the insect.

Once ingested and taken up into the insects’ cells, the RNA targets a specific gene essential for survival.

With the targeted protein no longer being produced, the beetle’s ability to thrive is impaired, therefore leading to decreased feeding and ultimately mortality, thereby reducing crop damage and improving yield.

The Value of RNAi based Pesticides

How RNAi works

RNA AgriBio Ltd is developing a new generation of crop protection based on a naturally occurring biological process called RNA interference (RNAi). Our technology uses Spray Induced Gene Silencing (SIGS), where a biodegradable RNA spray is applied to crops to specifically target harmful insect pests such as the Cabbage Stem Flea Beetle (CSFB) Psylliodes chrysocephela, one of the greatest threats to UK oilseed rape production.

  • Unlike conventional insecticides, RNA based sprays do not work by poisoning insects or affecting broad groups of organisms. Instead, it works with exceptional precision. The RNA molecules are designed to match only specific genetic sequences found within the target pest.

  • Importantly, this technology is not gene editing and does not alter the plant’s DNA. The crop itself is not genetically modified. The RNA acts more like a temporary biological instruction that naturally breaks down after use.

Our Team of Molecular Biologists & Regulatory specialists

Our Team

Dr Trevor Grigg, Founder & Director

CEO. Experienced Research Project Leader.
RNA biochemist, engineering biology,
agricultural entomology & agronomy.

Sereene Ghariani, Research Assistant

Molecular biologist, Bioinformatics, Insect biofeeding assays. Gene knockdown and mortality in Cabbage Stem Flea Beetle trials

Daisy Stradling, Research Assistant

Based at the John Innes Centre, Norwich. Microscopy imaging of RNA uptake into insect tissues. Glasshouse trials, insect and plant husbandry.

Prof. Tom Pope, Entomologist and CSFB expert at Harper Adams University

Current Chair of the Pests and Beneficials Working Group of the British Crop Protection Council.  A CSFB expert

Dr Roma Gwyn of Rationale Ltd., Biopesticide market consultant

Advice on UK & International regulatory pathways. Marketing strategy. Vice President of the International Biocontrol Manufacturers Association.

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